Saier M H, Reizer J
Department of Biology, University of California at San Diego, La Jolla 92093-0116.
Mol Microbiol. 1994 Sep;13(5):755-64. doi: 10.1111/j.1365-2958.1994.tb00468.x.
In 1964, Kundig, Ghosh and Roseman reported the discovery of the phosphoenolpyruvate:sugar phosphotransferase system (PTS). Thirty years later, we find that the PTS functions not only as a sugar-phosphorylating system, but also as a complex protein kinase system that regulates a wide variety of metabolic processes and controls the expression of numerous genes. As a result of recent operon- and genome-sequencing projects, novel PTS protein-encoding genes have been discovered, most of which have yet to be functionally defined. Some of them appear to be involved in cellular processes distinct from those recognized previously. Fundamental aspects of past and current PTS research are briefly reviewed, and recent advances are integrated into conceptual pictures that provide guides for future research.
1964年，昆迪格、戈什和罗斯曼报道了磷酸烯醇丙酮酸：糖磷酸转移酶系统（PTS）的发现。三十年后，我们发现PTS不仅作为一种糖磷酸化系统发挥作用，还作为一种复杂的蛋白激酶系统，调节多种代谢过程并控制众多基因的表达。由于最近的操纵子和基因组测序项目，已发现了新的PTS蛋白编码基因，其中大多数尚未进行功能定义。其中一些似乎参与了与先前认识的不同的细胞过程。本文简要回顾了过去和当前PTS研究的基本方面，并将最近的进展整合到概念图中，为未来的研究提供指导。
