Armstrong R A, Cairns N J, Lantos P L
Vision Sciences, Aston University, Birmingham, UK.
Neurosci Lett. 1997 May 23;227(3):193-6. doi: 10.1016/s0304-3940(97)00343-1.
The distribution and density of diffuse, primitive and classic beta-amyloid (A beta) deposits in the medial temporal lobe (MTL) was studied in cases of dementia with Lewy bodies (DLB) with and without associated Alzheimer's disease (AD) and 15 cases of sporadic AD. In the 'pure' DLB cases, virtually no A beta deposits were observed in the CA regions of the hippocampus or dentate gyrus whereas deposits were distributed throughout the MTL in DLB/AD and AD cases. Densities of diffuse and primitive A beta deposits were similar in AD and DLB/AD cases but density was significantly reduced in the 'pure' DLB cases. The density of the classic deposits was significantly reduced in DLB cases with or without associated AD compared with AD cases. These results suggest that A beta deposition in the MTL in 'pure' DLB cases is similar to that of elderly non-demented patients while, with the exception of the classic deposits, A beta deposition in DLB/AD cases is similar to that in cases of AD alone.
对伴有或不伴有相关阿尔茨海默病（AD）的路易体痴呆（DLB）患者以及15例散发性AD患者，研究了内侧颞叶（MTL）中弥漫性、原始性和典型β-淀粉样蛋白（Aβ）沉积物的分布和密度。在“单纯”DLB病例中，在海马体的CA区域或齿状回几乎未观察到Aβ沉积物，而在DLB/AD和AD病例中，沉积物分布于整个MTL。弥漫性和原始性Aβ沉积物的密度在AD和DLB/AD病例中相似，但在“单纯”DLB病例中密度显著降低。与AD病例相比，伴有或不伴有相关AD的DLB病例中典型沉积物的密度显著降低。这些结果表明，“单纯”DLB病例中MTL的Aβ沉积与老年非痴呆患者相似，而除典型沉积物外，DLB/AD病例中的Aβ沉积与单纯AD病例相似。
