Armstrong R A, Cairns N J, Myers D, Smith C U, Lantos P L, Rossor M N
Aston University, Birmingham.
Neurodegeneration. 1996 Mar;5(1):35-41. doi: 10.1006/neur.1996.0005.
The density of beta-amyloid (A beta) deposits was studied in the medial temporal lobe in non-demented individuals and in sporadic Alzheimer's disease (SAD) and Down's syndrome (DS). No A beta deposits were recorded in six of the non-demented cases, while in a further eight cases, these were confined to either the lateral occipitotemporal or parahippocampal gyrus. The mean density of A beta deposits in the cortex was greater in SAD and DS than in non-demented cases but with overlap between patient groups. The mean density of A beta deposits was greater in DS than SAD consistent with a gene dosage effect. The ratio of primitive to diffuse A beta deposits was greater in DS and in non-demented cases than in SAD and the ratio of classic to diffuse deposits was lowest in DS. In all groups, A beta deposits occurred in clusters which were often regularly distributed. In the cortex, the dimension of the A beta clusters was greater in SAD than in the non-demented cases and DS. The data suggest that the development of A beta pathology in the hippocampus could be a factor in the development of DS and SAD. Furthermore, the high density of A beta deposits, and in particular the high proportion of primitive type deposits, may be important in DS while the development of large clusters of A beta deposits may be a factor in SAD.
在非痴呆个体、散发性阿尔茨海默病（SAD）和唐氏综合征（DS）中，研究了内侧颞叶中β-淀粉样蛋白（Aβ）沉积物的密度。在6例非痴呆病例中未记录到Aβ沉积物，而在另外8例中，这些沉积物局限于枕颞外侧回或海马旁回。SAD和DS患者皮质中Aβ沉积物的平均密度高于非痴呆病例，但患者组之间存在重叠。DS中Aβ沉积物的平均密度高于SAD，这与基因剂量效应一致。DS和非痴呆病例中原始Aβ沉积物与弥漫性Aβ沉积物的比例高于SAD，经典Aβ沉积物与弥漫性Aβ沉积物的比例在DS中最低。在所有组中，Aβ沉积物呈簇状出现，且通常呈规则分布。在皮质中，SAD中Aβ簇的尺寸大于非痴呆病例和DS。数据表明，海马体中Aβ病理的发展可能是DS和SAD发展的一个因素。此外，Aβ沉积物的高密度，特别是原始类型沉积物的高比例，在DS中可能很重要，而Aβ沉积物大簇的形成可能是SAD的一个因素。
