Armstrong R A
Aston University, Birmingham, UK.
Dementia. 1995 May-Jun;6(3):121-5. doi: 10.1159/000106933.
The density of diffuse, primitive, classic and compact beta-amyloid (beta/A4) deposits was estimated in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease (AD). In the non-demented cases, beta/A4 deposits were absent in the hippocampus but in 8/14 cases they were present in the adjacent cortical regions. Variation in beta/A4 deposition in the non-demented cases was large and overlapped with that of the AD cases. The ratio of mature to diffuse beta/A4 deposits was greater in the non-demented than in the AD cases. In both the non-demented cases and AD, the beta/A4 deposits were clustered with, in many tissues, a regular distribution of clusters along the cortex parallel to the pia. However, the mean cluster size of the deposits in the cortex was greater in AD than in the non-demented cases. These results suggest that the spread of beta/A4 pathology between the modular units of the cortex and into the hippocampus could be important factors in the development of AD.
在老年非痴呆脑和阿尔茨海默病（AD）患者的内侧颞叶中，对弥漫性、原始性、典型性和致密性β-淀粉样蛋白（β/A4）沉积物的密度进行了估计。在非痴呆病例中，海马体中不存在β/A4沉积物，但在14例中有8例在相邻皮质区域存在该沉积物。非痴呆病例中β/A4沉积的变化很大，且与AD病例的变化有重叠。非痴呆病例中成熟β/A4沉积物与弥漫性β/A4沉积物的比例高于AD病例。在非痴呆病例和AD中，β/A4沉积物在许多组织中呈簇状分布，沿皮质与软脑膜平行呈规则分布。然而，AD患者皮质中沉积物的平均簇大小大于非痴呆病例。这些结果表明，β/A4病理学在皮质的模块化单元之间扩散并进入海马体可能是AD发病的重要因素。
