Klastersky J, Sadeghi M, Brihaye J
Surg Neurol. 1976 Aug;6(2):111-4.
A controlled double-blind study was performed on patients with injury to the head and face which had caused rhinorrhea or otorrhea. The patients were treated, at the time of the admission to the hospital, with penicillin (20 mega-units daily) or a placebo. A total of 52 patients was studied, 26 in each treatment group. Meningitis developed in one patient in the placebo group. Staphylococcus epidermidis (sensitive to penicillin) was the causative pathogen in this patient who also had a retained intraventricular foreign body. The frequency of extra-neurological infections and of asymptomatic pulmonary bacterial colonization was similar in both groups, but frequency of asymptomatic bacteriuria was higher in the placebo-treated patients.
对头部和面部受伤导致鼻漏或耳漏的患者进行了一项对照双盲研究。患者在入院时接受青霉素（每日2000万单位）或安慰剂治疗。共研究了52名患者，每个治疗组26名。安慰剂组有1名患者发生脑膜炎。该患者的致病菌为表皮葡萄球菌（对青霉素敏感），其脑室内还留有异物。两组的神经外感染频率和无症状肺部细菌定植频率相似，但接受安慰剂治疗的患者无症状菌尿的频率较高。
