An H S, Silveri C P, Simpson J M, File P, Simmons C, Simeone F A, Balderston R A
Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee 53226.
J Spinal Disord. 1994 Oct;7(5):369-73.
There have been numerous studies that implicate cigarette smoking as a risk factor for the development of back pain or disc disease. The purpose of this article is to review patients who underwent surgery for cervical or lumbar radiculopathy and to investigate the relationship between cigarette smoking and development of surgical disc disease. A cigarette smoking study of 205 surgical patients with lumbar and cervical disc diseases was done, with the surgical patients compared to 205 age-sex-matched inpatient controls during 1987-1988. This study was conducted at the Pennsylvania Hospital in Philadelphia, Pennsylvania. There were 163 patients with lumbar disc disease and 42 patients with cervical disc disease. The ratio of men to women was 1.5:1 for lumbar disc and 2.5:1 for cervical disc disease. Smoking history (current and ex-smokers) was strikingly increased in both prolapsed lumbar intervertebral disc (56% vs. 37% of controls, p = 0.00029) and cervical disc disease (64.3% vs. 37% of controls, p = 0.0025). Calculated relative risks for smokers were 2.2 for lumbar disc and 2.9 for cervical disc diseases. This association between cigarette smoking and disc disease was more significant when comparing between current smokers versus nonsmokers (p = 0.000011 for lumbar disc disease, and p = 0.00064 for cervical disc disease). Relative risks for current smokers were 3.0 for lumbar disc and 3.9 for cervical disc diseases. This correlation was significant for both males (p = 0.000068 for lumbar disc disease, p = 0.043 for cervical disc disease) and females (p = 0.018 for lumbar disc disease, p = 0.006 for cervical disc disease).(ABSTRACT TRUNCATED AT 250 WORDS)
已有大量研究表明，吸烟是背痛或椎间盘疾病发生的一个风险因素。本文旨在回顾接受颈椎或腰椎神经根病手术的患者，并探讨吸烟与手术性椎间盘疾病发生之间的关系。对205例患有腰椎和颈椎间盘疾病的手术患者进行了吸烟情况研究，并在1987 - 1988年期间将这些手术患者与205名年龄和性别匹配的住院对照者进行比较。该研究在宾夕法尼亚州费城的宾夕法尼亚医院进行。其中有163例腰椎间盘疾病患者和42例颈椎间盘疾病患者。腰椎间盘疾病患者中男女比例为1.5:1，颈椎间盘疾病患者中男女比例为2.5:1。在腰椎间盘突出症患者（56% vs. 对照组的37%，p = 0.00029）和颈椎间盘疾病患者中（64.3% vs. 对照组的37%，p = 0.0025），吸烟史（现吸烟者和既往吸烟者）显著增加。吸烟者患腰椎间盘疾病的相对风险为2.2，患颈椎间盘疾病的相对风险为2.9。当比较现吸烟者与非吸烟者时，吸烟与椎间盘疾病之间的这种关联更为显著（腰椎间盘疾病p = 0.000011，颈椎间盘疾病p = 0.00064）。现吸烟者患腰椎间盘疾病的相对风险为3.0，患颈椎间盘疾病的相对风险为3.9。这种相关性在男性（腰椎间盘疾病p = 0.000068，颈椎间盘疾病p = 0.043）和女性（腰椎间盘疾病p = 0.018，颈椎间盘疾病p = 0.006）中均具有显著性。（摘要截选至250字）
