Sensitivity of yeasts to lithium.

A wide range of tolerance to Li+ has been found among 12 different yeasts. Concentrations that do not allow long-term growth of an actively growing culture within 2-5 hr. At the same concentrations protein and RNA synthesis are inhibited with little or no lag period (less than 50 min) but respiration is not affected at these concentrations. Lower concentrations that do not inhibit growth, may impair sporulation. For given extracellular conditions, intracellular Li+ concentrations are lower in the more tolerant yeast strains.