Jaffar-Bandjee M C, Carrere J, Bally M, Chazalette J P, Galabert C
Laboratoire de Biologie, Hôpital R. Sabran, Hyères, France.
Pathol Biol (Paris). 1994 May;42(5):505-9.
The authors have studied the production of exoproteins by Pseudomonas aeruginosa in the sputa of 18 patients suffering from cystic fibrosis, during 29 bronchopulmonary exacerbations and also after the recovery of a stable state. Significant levels of exoproteins were detected but with a large heterogenity of intra and inter individual variations. A significant decrease in the production of the three exoproteins was found after twelve days of antibiotherapy, without any correlation between exoprotein levels and colony forming units in the sputa. During the intercrisis phase, exoproteins levels were practically undetectable. These facts and the good correlation between clinical symptoms support the hypothesis of a renewal of virulence of Pseudomonas aeruginosa during these periods of bronchopulmonary exacerbation in cystic fibrosis.
作者研究了铜绿假单胞菌在18例囊性纤维化患者痰液中的外蛋白产生情况，观察了29次支气管肺加重期以及病情恢复到稳定状态后的情况。检测到外蛋白水平显著，但个体内和个体间存在很大差异。抗生素治疗12天后，三种外蛋白的产生显著减少，痰液中外蛋白水平与菌落形成单位之间无任何相关性。在病情缓解期，外蛋白水平几乎检测不到。这些事实以及与临床症状的良好相关性支持了在囊性纤维化患者支气管肺加重期，铜绿假单胞菌毒力恢复的假说。
