Watanabe C, Satoh H
Department of Environmental Health Sciences, Tohoku University School of Medicine, Sendai, Japan.
Physiol Behav. 1994 Nov;56(5):927-32. doi: 10.1016/0031-9384(94)90325-5.
The influence of Se deficiency on behavioral development in preweanling mice was evaluated. Female ICR mice were fed either Se-deficient or control diet (containing < 20 or 400 ng Se/g diet, respectively) from 4 weeks before conception to the end of the suckling period. In the offspring of Se-deficient dams, liver and brain Se levels were reduced to < 5% and 60% of those in the control offspring, respectively, from as early as the third postnatal day. At weaning, brain Se content exceeded the hepatic one in Se-deficient offspring, whereas in the control offspring the liver contained 10 times more Se than the brain did. Thus, tissue-specific metabolism of Se was already functioning during the neonatal period. When placed in a thermogradient and allowed to move along the gradient, Se-deficient offspring exhibited a preference for a significantly warmer environment than did the controls. They also showed slightly retarded development of walking ability. These results showed that Se-deficient offspring differed from the controls in behavioral development. Possible mechanisms of these alterations are discussed.
评估了缺硒对断奶前小鼠行为发育的影响。从受孕前4周直到哺乳期结束，给雌性ICR小鼠分别喂食缺硒饮食或对照饮食（分别含<20或400 ng硒/克饮食）。在缺硒母鼠的后代中，早在出生后第三天，肝脏和大脑中的硒水平就分别降至对照后代的<5%和60%。断奶时，缺硒后代大脑中的硒含量超过肝脏，而对照后代肝脏中的硒含量比大脑多10倍。因此，硒的组织特异性代谢在新生儿期就已发挥作用。当置于温度梯度环境中并允许沿梯度移动时，缺硒后代比对照后代更倾向于选择明显更温暖的环境。它们还表现出步行能力发育略有迟缓。这些结果表明，缺硒后代在行为发育方面与对照后代不同。文中讨论了这些改变可能的机制。
