Johnson A E, Coirini H, Källström L, Wiesel F A
Psychiatry Department, University Hospital, Uppsala University, Sweden.
Neuroreport. 1994 Sep 8;5(14):1836-8. doi: 10.1097/00001756-199409080-00038.
Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [125I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 subtype. However, contrary to previously published data, [125I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances.
开展实验以确定大鼠基底神经节关键的纹状体外区域——丘脑底核（STh）内多巴胺（DA）受体的分布和结合特征。对[125I]NCQ - 298放射自显影片的分析表明，D2受体家族的结合位点在STh中丰富。竞争研究表明这些位点具体属于D2亚型。然而，与先前发表的数据相反，[125I]SCH - 23982放射自显影片未能揭示STh中D1受体结合。这些数据表明作用于D2受体的DA可能直接调节STh神经活动，而且抗精神病药物对STh D2受体结合的拮抗作用可能与锥体外系运动障碍的表达有关。
