Grehl H, Kaschka W P
Psychiatrische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.
Fortschr Neurol Psychiatr. 1994 Nov;62(11):413-6. doi: 10.1055/s-2007-1002298.
All parts of the central nervous system may be involved in HIV infection, resulting in a variety of neuropsychiatric syndromes some of which resemble functional psychoses. Corresponding to the HIV-associated disease these syndromes differ in course and severity. A very common form is the AIDS-dementia complex, especially late in the course of disease. Up to now, however, a specific therapy is not available. A case of severe psychosis with paranoid delusions and hallucinations in a patient with otherwise asymptomatic HIV infection is reported. From her biography it was concluded that the infection occurred 10 years earlier. During therapy with azidothymidine, symptoms disappeared within 3 months, and more than one year after admission to our hospital the patient was still able to work. According to the course of the disease in this patient, reports from the literature and pathogenetic theories, an early therapy with antiviral agents is recommended in HIV-induced subacute encephalitis.
中枢神经系统的所有部分都可能受到HIV感染的影响，从而导致各种神经精神综合征，其中一些类似于功能性精神病。与HIV相关疾病相对应，这些综合征在病程和严重程度上有所不同。一种非常常见的形式是艾滋病痴呆综合征，尤其是在疾病后期。然而，到目前为止，尚无特异性治疗方法。本文报道了1例在其他方面无症状的HIV感染患者出现伴有偏执妄想和幻觉的严重精神病病例。从她的病史推断，感染发生在10年前。在接受齐多夫定治疗期间，症状在3个月内消失，入院1年多后该患者仍能工作。根据该患者的病程、文献报道及发病机制理论，对于HIV引起的亚急性脑炎，建议早期使用抗病毒药物进行治疗。
