Uterine skin grafts and fertility control in the rat.

Autologous intrauterine skin grafting was studied as a method of fertility control in the rat. Skin taken from the ear was grafted onto the right horn in 52 rats. All skin grafts "took" and developed into one of three forms: (1) replacement of endometrium over a wide area, (2) polypoid formations, or (3) skin bridges. Curettage before the skin grafting did not affect the "take" or subsequent course of the graft. After mating, no pregnancy occurred in skin-grafted horns, whereas control horns behaved like those in control rats. Results obtained in rat uteri indicate another approach to the treatment of uterine bleeding and possibly to contraception.