Woodward W E, Gilman R H, Hornick R B, Libonati J P, Cash R A
Dev Biol Stand. 1976;33:108-12.
A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.
一种口服减毒活霍乱疫苗已给予志愿者，安全性良好。疫苗菌株似乎在肠道内容物中大量繁殖，并引发了明显的杀弧菌抗体反应。随后用强毒稻叶型弧菌进行攻击，结果显示对临床疾病和弧菌排出有显著的保护作用。文中还讨论了回复产生毒素的可能性。
