Botz C K, Leibel B S, Zingg W, Gander R E, Albisser A M
Diabetes. 1976 Aug;25(8):691-700. doi: 10.2337/diab.25.8.691.
This study was undertaken to determine the different consequences of portal and peripheral routes of insulin administration by the artificial endocrine pancreas. Intraportal glucose was infused (10 mg./min./kg. for 60 minutes) in anesthetized normal and pancreatectomized dogs while blood glucose concentrations were monitored continuously. During computer-controlled insulin administration normal glucose tolerance was restored by both portal and peripheral routes of insulin delivery. There were also no significant differences in (1) glycemic patterns, (2) insulin infusion patterns, (3) peripheral IRI levels, and (4) total insulin requirements between the two routes. It is apparent that the peripheral route, which is more readily accessible than the portal route, may be an appropriate infusion site for an implantable or portable prosthesis for controlling blood glucose concentration.
本研究旨在确定人工内分泌胰腺经门静脉和外周途径注射胰岛素的不同后果。在麻醉的正常和胰腺切除犬中输注门静脉葡萄糖（10mg/分钟/千克，持续60分钟），同时连续监测血糖浓度。在计算机控制的胰岛素给药过程中，通过门静脉和外周途径输送胰岛素均可恢复正常糖耐量。在（1）血糖模式、（2）胰岛素输注模式、（3）外周IRI水平和（4）两种途径之间的总胰岛素需求量方面也没有显著差异。显然，外周途径比门静脉途径更容易接近，可能是用于控制血糖浓度的可植入或便携式假体的合适输注部位。
