Mauer S M, Miller K, Goetz F C, Barbosa J, Simmons R L, Najarian J S, Michael A F
Diabetes. 1976 Aug;25(8):709-12. doi: 10.2337/diab.25.8.709.
Kidneys of patients with severe diabetic nephropathy demonstrate marked linear immunofluorescent staining of extracellular membranes, including the tubular and glomerular basement membranes (TBM and GBM) and Bowman's capsule. Immunofluorescent studies were carried out on kidney tissue obtained from 12 diabetic and 17 nondiabetic patients from two to 12 years following renal transplantation. The frequency and intensity of SgG and albumin staining of these membranes were significantly greater in the diabetic than in the nondiabetic patients (P less than 0.0005). TBM, GBM, and Bowman's capsule staining did not occur in any of the seven kidneys studies at the time of their transplantation into diabetic recipients. Thus, the abnormalities leading to the deposition or trapping of proteins in renal extracellular membranes occur early after the placement of normal kidneys into the abnormal metabolic environment of the diabetic transplant recipient. The present study supports the concept that basement membrane alterations in diabetes are a consequence of the biochemical perturbations of diabetes rather than a separately inherited genetically linked disorder.
重症糖尿病肾病患者的肾脏显示细胞外膜有明显的线性免疫荧光染色，包括肾小管和肾小球基底膜（TBM和GBM）以及鲍曼囊。对12例糖尿病患者和17例非糖尿病患者肾移植后2至12年获得的肾组织进行了免疫荧光研究。这些膜的SgG和白蛋白染色频率及强度在糖尿病患者中显著高于非糖尿病患者（P小于0.0005）。在移植到糖尿病受者时，所研究的7个肾脏中均未出现TBM、GBM和鲍曼囊染色。因此，导致蛋白质在肾细胞外膜沉积或潴留的异常情况，在将正常肾脏置于糖尿病移植受者的异常代谢环境后早期就会出现。本研究支持这样一种观点，即糖尿病中的基底膜改变是糖尿病生化紊乱的结果，而不是一种单独遗传的基因相关疾病。
