[Therapy of duodenal ulcer. Comparative study on the hospital treatment of duodenal ulcer under endoscopic control of progress with and without drug support].

In a controlled study of 4 weeks--performed on 3 groups of 15 hospitalized patients each with endoscopically demonstrated florid duodenal ulcers--the healing process was checked by endoscope after 14 days and 4 weeks. The first group was treated with the preparation Caved-S, the second received an antacid mixture, and the third group was at first given no specific therapy but a placebo and later on an additional small quantity of antacids. The quickest relief of the pain symptoms was seen in the group treated with Caved-S. Healing was assessed endoscopically after the scheme of Ohmori and Miva and yielded after 14 days a varying number of healing stages for all 3 groups; after 4 weeks there was positive healing-up in a varying number of patients. All 45 patients were clearly improved after 4 weeks. The healing rate in those who had received Caved-S was slightly better than in those who had been treated with antacids and significantly better than in those patients who had been given small quantities of antacids only later on. It becomes apparent again that hospitalization alone leads to ulcer healing in over 60% of cases, which excludes the evidence of an influence of drugs.