Weingart J, Kunert H
Fortschr Med. 1981 Feb 26;99(8):278-82.
The neutralization of acid by antacids and the inhibition of acid secretion by H2-receptor antagonists are the two essential factors in the standard therapy for peptic ulcer disease. In order to determine whether a high dosage therapy with a calcium-containing antacid accelerates the healing of the ulcer or retards it through the "Acid-rebound" effect of the calcium, we examined in a clinical study 10 patients with an endoscopically proven duodenal ulcer. After 2 weeks the duodenal ulcer was healed in 5 of the 10 patients. Thus a rate of healing was attained which was achieved in our clinic with a daily dosage of 1200 mg or 800 mg of cimetidine or with a Mg/Al-hydroxide-containing antacid in a daily dosage of 560 mval neutralization capacity in duodenal ulcer patients. On the other hand there was a difference in the healing of the ulcer between the methods of treatment presented and the exclusive dose of a placebo.
抗酸剂中和胃酸以及H2受体拮抗剂抑制胃酸分泌是消化性溃疡疾病标准治疗中的两个关键因素。为了确定含钙抗酸剂的高剂量疗法是加速溃疡愈合还是通过钙的“酸反跳”效应延缓愈合，我们在一项临床研究中检查了10例经内镜证实为十二指肠溃疡的患者。2周后，10例患者中有5例十二指肠溃疡愈合。因此，获得的愈合率与我们诊所使用每日剂量1200 mg或800 mg西咪替丁或每日剂量560 mval中和能力的含镁/铝抗酸剂治疗十二指肠溃疡患者所达到的愈合率相同。另一方面，所呈现的治疗方法与单纯使用安慰剂剂量之间在溃疡愈合方面存在差异。
