Morris T H, Sorensen S H, Turkington J, Batt R M
Department of Laboratory Animal Science, SmithKline Beecham Pharmaceuticals, Harlow, Essex.
Lab Anim. 1994 Oct;28(4):313-9. doi: 10.1258/002367794780745047.
Repeated episodes of diarrhoea were seen in 4 laboratory beagles after experimental renal surgery and feeding a modified diet. Small intestinal bacterial overgrowth (SIBO) was suspected by exclusion of other causes and measurement of plasma folate. SIBO was confirmed by quantitative duodenal bacteriology. Beagles with SIBO can show no clinical signs, experimental stress and dietary change may have been reasons why these 4 beagles exhibited clinical signs with SIBO. Despite normal gut histology an increase in gut permeability was found using sugar absorption tests. This increased permeability had the potential to cause variations in drug absorption during experimental studies.
在4只实验用比格犬接受实验性肾脏手术后并喂食改良饮食后，出现了反复腹泻的情况。通过排除其他病因并检测血浆叶酸水平，怀疑存在小肠细菌过度生长（SIBO）。通过定量十二指肠细菌学检查确诊为SIBO。患有SIBO的比格犬可能没有临床症状，实验应激和饮食变化可能是这4只比格犬出现SIBO临床症状的原因。尽管肠道组织学正常，但通过糖吸收试验发现肠道通透性增加。这种通透性增加有可能在实验研究期间导致药物吸收的变化。
