Patti J M, Höök M
Institute of Biosciences and Technology, Texas A & M University, Houston 77030.
Curr Opin Cell Biol. 1994 Oct;6(5):752-8. doi: 10.1016/0955-0674(94)90104-x.
Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.
微生物表达一类细胞表面粘附素，它们能特异性识别并结合细胞外基质的成分。微生物与宿主组织的粘附是多种感染发生过程中的关键阶段。最近的研究聚焦于分子水平上微生物附着的机制，包括鉴定革兰氏阳性菌几种细胞表面粘附素中的配体结合结构域以及构建粘附素缺陷的同基因突变体。
