Karter D L, Karter A J, Yarrish R, Patterson C, Kass P H, Nord J, Kislak J W
Infectious Disease Section, St. Vincent's Hospital, New York City, New York 10011.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):199-203.
The prevalence of vitamin A deficiency and its association with dietary retinol intake in patients with AIDS was assessed in a cross-sectional study. Sixty eligible patients with AIDS provided serum samples that were analyzed for retinol content. Exclusion criteria included current use of vitamin supplements (57% of the 140 willing to participate) and pregnancy (none). Past dietary intake was determined using a standardized food intake frequency questionnaire. The prevalence of hyporetinemia was 22%. This was a 241-fold greater prevalence than that of a representative sample of the U.S. population, after adjusting for age and sex. There was a positive association between serum retinol status and dietary intake, but 27% of those with adequate intake had serum retinol levels below the normal range. These findings suggest that regardless of intake, patients with AIDS may represent a population at considerable risk of vitamin A deficiency.
在一项横断面研究中，评估了艾滋病患者维生素A缺乏的患病率及其与膳食视黄醇摄入量的关系。60名符合条件的艾滋病患者提供了血清样本，对其视黄醇含量进行了分析。排除标准包括当前使用维生素补充剂（140名愿意参与者中的57%）和妊娠（无）。过去的膳食摄入量通过标准化的食物摄入频率问卷来确定。低视黄醇血症的患病率为22%。在调整年龄和性别后，这一患病率比美国人群的代表性样本高241倍。血清视黄醇水平与膳食摄入量之间存在正相关，但摄入量充足的患者中有27%的血清视黄醇水平低于正常范围。这些发现表明，无论摄入量如何，艾滋病患者可能是维生素A缺乏风险相当高的人群。
