Mo Q, Gong B, Fang J, Li J, Huang J, Chen K, Kuang X, Wang J
Shanghai University of TCM.
Zhen Ci Yan Jiu. 1994;19(1):33-6.
5-HT and muscarine (M) receptors total binding capacities (Rt) in different brain areas and spleen were determined using receptor radioligand binding assay (RLBA) after needling zusanli of rats. And the rats without needling and needling Taichong point were used as control. These results showed that 5-HT and M receptors Rt were decreased obviously than control group in rat's cerebral cortex, hippocampus, striatum, spinal cord and spleen when needling zusanli can produce obvious acupuncture analgesia. 5-HT Rt in brain stem and medulla oblongata was obviously decreased and not changed in thalamus. M receptor Rt value was not changed clearly in brain stem and medulla oblongata as well, but it was obviously decreased in thalamus. These results showed that effects of acupoints on Various meridians are different, thus the results of acupuncture at Zusanli are distinct from taichong.
采用受体放射配体结合分析法（RLBA）测定大鼠针刺足三里后不同脑区及脾脏中5-羟色胺（5-HT）和毒蕈碱（M）受体的总结合容量（Rt）。将未针刺及针刺太冲穴的大鼠作为对照。结果显示，当针刺足三里能产生明显的针刺镇痛作用时，大鼠大脑皮层、海马、纹状体、脊髓及脾脏中的5-HT和M受体Rt较对照组明显降低。脑干和延髓中的5-HT Rt明显降低，丘脑则无变化。脑干和延髓中的M受体Rt值也无明显变化，但丘脑明显降低。这些结果表明，不同经络穴位的作用不同，因此足三里穴针刺结果与太冲穴不同。
