Liu C, Zhao F, Zhu L
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
Zhen Ci Yan Jiu. 1994;19(1):59-62, 54.
In the present investigation the intensity of stimulated electro-acupuncture (EA) was measured by electrophysiological collision technique. In the behavioral experiments, by applying the weak electro-acupuncture pulses (50 Hz, 1-1.5mA), not enough to activated A delta afferent fibers, to Yanglingquan and Xuanzhong points, the latency of nociceptive hind limb withdrawal reflex, but not tail-flick latency was prolonged. Administered intraperitoneally, both theophylline and caffeine, P1-purinergic (adenosine) receptor antagonists, could block the electroacupuncture-induced elevation of the nociceptive thresholds in a dose-effect related manner, whereas dipyridamole, an inhibitor of adenosine release, could shorten the after of electro-acupuncture in a dose dependent way. These results suggest that weak electro-acupuncture may induce analgesia and purines appear to be involved in this process.
在本研究中，通过电生理碰撞技术测量了刺激电针（EA）的强度。在行为实验中，对阳陵泉和悬钟穴施加不足以激活Aδ传入纤维的弱电针脉冲（50Hz，1 - 1.5mA），伤害性后肢退缩反射的潜伏期延长，但甩尾潜伏期未延长。腹腔注射P1 - 嘌呤能（腺苷）受体拮抗剂茶碱和咖啡因，可剂量依赖性地阻断电针诱导的伤害性阈值升高，而腺苷释放抑制剂双嘧达莫则可剂量依赖性地缩短电针的作用时间。这些结果表明，弱电针可能诱导镇痛作用，嘌呤似乎参与了这一过程。
