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辣椒素治疗坐骨神经对大鼠痛阈及针刺镇痛效果的影响

[Influence of capsaicin treating sciatic nerve on the pain threshold and the effect of acupuncture analgesia of rats].

作者信息

Xu R, Guan X, Wang C

机构信息

Department of Neurobiology, Tongji Medical University, Wuhan.

出版信息

Zhen Ci Yan Jiu. 1993;18(4):280-4.

PMID:7923734
Abstract

The model of local application of 1.5% Capsaicin (Cap) on the right sciatic nerve and control of Vehicle (Veh) on the left were used. The influence of Cap on pain threshold, electroacupuncture (EA) analgesia and Fluoride-resistant acid phosphatase (FRAP) activity in the dorsal horn of spinal cord were observed. The results showed, the pain threshold of Cap treatment side rose significantly compared with the control side, FRAP in dorsal horn of spinal cord vanished, and the analgesic effect of EA at "Huantiao" of the Cap treatment side markedly decreased, compared with not only that EA at the control side but also that EA before Cap treatment. It is indicated that the C fibers of the primary afferent participate in the input of pain and EA analgesic information.

摘要

采用右侧坐骨神经局部应用1.5%辣椒素(Cap)而左侧应用赋形剂(Veh)作为对照的模型。观察Cap对痛阈、电针(EA)镇痛以及脊髓背角耐氟酸性磷酸酶(FRAP)活性的影响。结果显示,与对照侧相比,Cap处理侧的痛阈显著升高,脊髓背角的FRAP消失,并且Cap处理侧“环跳”穴处EA的镇痛效果与对照侧EA以及Cap处理前EA相比均显著降低。表明初级传入C纤维参与疼痛和EA镇痛信息的传入。

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