Xing R D, Wang Z S, Li C Q, Tang Q Y, Jiang C B, Zhang Y Z
Department of Oral and Maxillofacial Surgery, 2nd Teaching Hospital, Hebei Medical College, Shijiazhuang - People's Republic of China.
Int J Biol Markers. 1994 Oct-Dec;9(4):239-42.
Serum sialic acid levels were measured in 80 healthy subjects, in 60 patients with benign tumors and in 110 patients with oral cancer. It was shown that these levels were significantly elevated in oral cancer patients compared to healthy controls and patients with benign tumors (p < 0.01); they were higher in patients with stage III and stage IV disease than in those with stage I and II disease (p < 0.01). However, no difference was observed between healthy controls and stage I and II cancer patients. The results of this study suggest that the determination of sialic acid levels may be of value in the diagnosis of oral cancer, but its usefulness as an adjunct in clinical staging is limited.
对80名健康受试者、60名患有良性肿瘤的患者以及110名口腔癌患者进行了血清唾液酸水平测定。结果显示，与健康对照组和良性肿瘤患者相比，口腔癌患者的这些水平显著升高（p < 0.01）；III期和IV期疾病患者的水平高于I期和II期疾病患者（p < 0.01）。然而，在健康对照组与I期和II期癌症患者之间未观察到差异。本研究结果表明，唾液酸水平的测定可能对口腔癌的诊断有价值，但其作为临床分期辅助手段的作用有限。
