Govaert T M, Sprenger M J, Dinant G J, Aretz K, Masurel N, Knottnerus J A
Department of General Practice, University of Limburg, Maastricht, The Netherlands.
Vaccine. 1994 Oct;12(13):1185-9. doi: 10.1016/0264-410x(94)90241-0.
The objective of this study was to determine the immune response to influenza vaccination in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood was taken from 1838 people aged 60 years and older, prior to injection with the influenza vaccine or a placebo. A second blood sample was taken three weeks later. The antibody reaction was measured by comparing the geometric mean titre and the percentage of participants who had a protective antibody titre before and after vaccination and for all sera of each strain. A protective antibody titre was found in 43-68% of those who had received the vaccine, depending on the strain investigated. Patients potentially at risk showed a response similar to the other participants. We conclude that influenza vaccination in elderly people provides a reasonable to good immune response. Research is needed on whether a good immune response decreases the incidence of influenza.
本研究的目的是通过一项随机、双盲、安慰剂对照试验，确定老年人对流感疫苗的免疫反应。在给1838名60岁及以上的人注射流感疫苗或安慰剂之前，采集静脉血。三周后采集第二份血样。通过比较几何平均滴度以及接种疫苗前后具有保护性抗体滴度的参与者百分比，对每种毒株的所有血清进行抗体反应测量。根据所研究的毒株，在43%-68%接种疫苗的人中发现了保护性抗体滴度。有潜在风险的患者表现出与其他参与者相似的反应。我们得出结论，老年人接种流感疫苗可产生合理至良好的免疫反应。关于良好的免疫反应是否会降低流感发病率，还需要进行研究。
