Baker H, Frank O, DeAngelis B, Baker E R
Department of Preventive Medicine and Community Health and Medicine, New Jersey Medical School, Newark 07107.
Antimicrob Agents Chemother. 1994 Oct;38(10):2458-9. doi: 10.1128/AAC.38.10.2458.
An analytical system comprising a bacterium and a protozoan was used to pinpoint the metabolic lesion whereby chlorhexidine (CLX) produced cell death. Nicotinic acid but not nicotinamide annulled the biocidal action of CLX. The results suggest that CLX may not permit bioconversion of nicotinamide to nicotinic acid to annul the growth inhibition induced by CLX.
一个由细菌和原生动物组成的分析系统被用来确定洗必泰（CLX）导致细胞死亡的代谢损伤。烟酸而非烟酰胺消除了CLX的杀菌作用。结果表明，CLX可能不允许烟酰胺生物转化为烟酸以消除CLX诱导的生长抑制。
