与铝一起服用时氧氟沙星的口服吸收情况。 你提供的原文“Oral absorption of ofloxacin administered together with aluminum.”中多了一个“of”，正确表述应该是“Oral absorption of ofloxacin administered together with aluminum.” 。
Oral absorption of ofloxacin administered together with aluminum.
作者信息
Sánchez Navarro A, Martínez Cabarga M, Dominguez-Gil Hurlé A
机构信息
Department of Pharmacy and Pharmaceutical Technology, Facultad de Farmacia, University of Salamanca, Spain.
出版信息
Antimicrob Agents Chemother. 1994 Oct;38(10):2510-2. doi: 10.1128/AAC.38.10.2510.
A clinical study was carried out to establish the influence of aluminum on the oral absorption of ofloxacin. Ten healthy volunteers were included in a crossover study based on a Latin square design. The treatments that all volunteers received were A, consisting of 400 mg of ofloxacin, and B, consisting of 400 mg of ofloxacin plus 11 g of colloidal aluminum phosphate. The absorption constant and other ofloxacin parameters were calculated from data on levels in plasma by using model-independent calculation methods. There were no statistically significant differences between the mean values of the areas under the curve corresponding to the administration of ofloxacin alone and those of ofloxacin with aluminum. Regarding the other pharmacokinetic parameters, a significant difference between the absorption constants was found. The presence of aluminum reduces the absorption rate of this quinolone but does not modify the percentage of the absorbed dose.
开展了一项临床研究以确定铝对氧氟沙星口服吸收的影响。基于拉丁方设计，10名健康志愿者参与了一项交叉研究。所有志愿者接受的治疗方案为：A，包含400毫克氧氟沙星；B，包含400毫克氧氟沙星加11克胶体磷酸铝。通过使用与模型无关的计算方法，根据血浆水平数据计算吸收常数及其他氧氟沙星参数。单独给予氧氟沙星和给予氧氟沙星加铝时，曲线下面积的平均值之间无统计学显著差异。关于其他药代动力学参数，发现吸收常数存在显著差异。铝的存在降低了这种喹诺酮类药物的吸收速率，但不改变吸收剂量的百分比。
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