Martínez Cabarga M, Sánchez Navarro A, Colino Gandarillas C I, Domínguez-Gil A
Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain.
Antimicrob Agents Chemother. 1991 Oct;35(10):2102-5. doi: 10.1128/AAC.35.10.2102.
A study was performed to establish the effect of Al3+ and Fe2+ cations on the absorption of ofloxacin when it is administered orally at a dose of 200 mg. The study was carried out with nine volunteers, who each received three treatments (A [200 mg of ofloxacin], B [200 mg of ofloxacin plus 11 g of colloidal aluminum phosphate], and C [200 mg of ofloxacin plus 1,050 mg of FeSO4]) according to a Latin square design; the washout period was 1 week. The analytical technique was a microbiological diffusion method. The pharmacokinetic parameters were calculated from the cumulative urinary excretion data and from a sigma-minus plot. The total amount of ofloxacin excreted in urine had a mean value of 163.59 +/- 22.13 mg when ofloxacin was administered alone, 152.41 +/- 18.76 mg when it was administered with Al3+, and 146.49 +/- 14.85 mg when it was administered with Fe2+. No statistically significant differences were found in the F values (fractions of dose absorbed) obtained with ofloxacin alone and ofloxacin plus Al3+ (P = 0.341). When ofloxacin alone was compared with joint administration with Fe2+ the value of F decreased 10.85%; this difference is statistically significant (P = 2.623 x 10(-2)).
进行了一项研究，以确定Al3+和Fe2+阳离子对口服200mg剂量氧氟沙星吸收的影响。该研究对9名志愿者进行，他们每人根据拉丁方设计接受三种治疗（A[200mg氧氟沙星]、B[200mg氧氟沙星加11g胶体磷酸铝]和C[200mg氧氟沙星加1050mg硫酸亚铁]）；洗脱期为1周。分析技术为微生物扩散法。根据累积尿排泄数据和sigma减图计算药代动力学参数。单独给予氧氟沙星时，尿中氧氟沙星排泄总量的平均值为163.59±22.13mg，与Al3+合用时为152.41±18.76mg，与Fe2+合用时为146.49±14.85mg。单独使用氧氟沙星和氧氟沙星加Al3+时获得的F值（吸收剂量分数）无统计学显著差异（P=0.341）。当单独使用氧氟沙星与与Fe2+联合给药相比时，F值下降了10.85%；这种差异具有统计学显著性（P=2.623×10-2）。
