疑似艾滋病和艾滋病相关综合征患者血清中抗HIV和抗HTLV-I抗体的不同反应性

Differential reactivities of antibodies to HIV and HTLV-I in sera of suspected AIDS and ARC patients.

作者信息

Aidoo M, Nishiwaki O, Akari H, Brandful J A, Ampofo W, Hayami M, Ayisi N K

机构信息

Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.

出版信息

West Afr J Med. 1994 Jul-Sep;13(3):150-1.

PMID:7841103

Abstract

Sera collection from 255 clinically diagnosed AIDS and ARC patients were analyzed for antibodies to HIV and HTLV-I by Western blot and particle agglutination methods respectively. Antibodies to HIV were detected in 37.3% of the sera collected as compared to 5.5% for HTLV-I. Most (95%) of the HIV positive sera had dual reactivity to both HIV-I and HIV-2. Antibodies to HTLV-1 were more frequently detected in HIV positive sera (11.58%) than in HIV negative sera (1.88%). Conversely, antibodies to HIV were detected twice as frequently in HTLV-1 positive sera (78.6%) than in HTLV-1 negative sera (34.85%).

摘要

分别采用蛋白质印迹法和颗粒凝集法，对255例临床诊断为艾滋病和艾滋病相关综合征（ARC）患者的血清进行了抗HIV和抗HTLV-I抗体检测。检测发现，37.3%的采集血清中存在抗HIV抗体，而抗HTLV-I抗体的比例为5.5%。大多数（95%）HIV阳性血清对HIV-1和HIV-2均呈双重反应性。抗HTLV-1抗体在HIV阳性血清中（11.58%）的检出频率高于HIV阴性血清（1.88%）。相反，抗HIV抗体在HTLV-1阳性血清中的检出频率（78.6%）是HTLV-1阴性血清（34.85%）的两倍。