Nakamura Y, Hirose K, Yanagawa H, Kato H, Kawasaki T
Department of Public Health, Jichi Medical School, Minamikawachi, Japan.
Acta Paediatr. 1994 Oct;83(10):1061-4. doi: 10.1111/j.1651-2227.1994.tb12986.x.
To calculate the incidence of recurrent Kawasaki disease and to discuss some potential risk factors for its recurrence, we observed a cohort consisting of those followed-up since the first episode of the disease. A total of 4560 persons, with 16,500.4 person-years were observed from the second month after the first episode of the disease to the end of 1989. The mean observation period was 3.62 years. The overall incidence rate was 5.21 per 1000 person-years, with a higher incidence within the 2 years from the first episode; although not statistically significant, the incidence was higher among males and those who experienced the first episode at < or = 2 years of age. The possibility of i.v. gamma globulin therapy being one of the risk factors was negated by a stratified analysis to control confounding factors but supported by univariate analysis.
为了计算川崎病复发的发生率并探讨其复发的一些潜在风险因素，我们观察了一组自疾病首次发作起就接受随访的人群。从疾病首次发作后的第二个月到1989年底，共观察了4560人，观察人年数为16500.4人年。平均观察期为3.62年。总发病率为每1000人年5.21例，在首次发作后的2年内发病率较高；虽然无统计学意义，但男性以及在2岁及以下经历首次发作的人群发病率较高。通过分层分析以控制混杂因素否定了静脉注射丙种球蛋白治疗是风险因素之一的可能性，但单因素分析支持这一可能性。
