Greco L, Tipo V, Di Donato F, Mayer M
Department of Paediatrics, University of Naples, Italy.
Acta Paediatr. 1994 Jul;83(7):724-9. doi: 10.1111/j.1651-2227.1994.tb13127.x.
Catch-up growth in coeliac disease was thought to be a continuous process and hence linear models have been proposed to interpret the pattern of catch-up growth. Observed longitudinal data do not fit a linear model adequately. The aim of this study is to clarify the pattern of short-term catch-up growth in coeliac patients. Twenty-one coeliac children (aged 6-24 months) entered the study and were monitored at short-time intervals. All showed a "pulsatile" pattern of growth velocity for height, weight, leg length, subscapular and triceps skinfolds. Peaks alternated with troughs at a mean time of 62 days for the whole set of measurements. The periodicity was remarkably stable. The size of the peaks decreased with time on a gluten-free diet. Catch-up growth is a discontinuous process made up of a sequence of bursts of growth followed by a resting phase. This provides strong evidence for the possibility that short-term growth may be pulsatile.
乳糜泻的追赶生长曾被认为是一个持续的过程，因此有人提出用线性模型来解释追赶生长的模式。但观察到的纵向数据并不能很好地拟合线性模型。本研究的目的是阐明乳糜泻患者短期追赶生长的模式。21名乳糜泻儿童（年龄在6 - 24个月之间）进入研究，并接受短时间间隔的监测。所有儿童的身高、体重、腿长、肩胛下和三头肌皮褶厚度的生长速度均呈现“脉冲式”模式。对于整套测量指标，峰值与谷值交替出现的平均时间为62天。这种周期性非常稳定。在无麸质饮食条件下，峰值的大小随时间减小。追赶生长是一个由一系列生长爆发期和随后的静止期组成的不连续过程。这为短期生长可能呈脉冲式提供了有力证据。
