Reanmongkol W, Matsumoto K, Itharat A, Watanabe H
Division of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
Biol Pharm Bull. 1994 Sep;17(9):1206-9. doi: 10.1248/bpb.17.1206.
Analgesic activities of Randia siamensis CRAIB (R. siamensis) extract and pseudoginsenoside-RP1, a constituent of the extract, were examined in the writhing test, hot plate test and Randall-Selitto test. Oral administration of R. siamensis extract dose-dependently decreased the number of writhings and stretchings induced by 0.6% acetic acid in the writhing test in mice. Moreover, in the Randall-Selitto test in rats, the extract raised the nociceptive threshold of the carrageenan-inflamed but not of non-inflamed paw. It did not affect the nociceptive response in the hot plate test in mice. The R. siamensis extract did not affect hexobarbital-induced sleep or spontaneous motor activity in mice, suggesting that it has no sedative effect. Pseudoginsenoside-RP1 produced similar effects to the R. siamensis extract, but its effective doses in the analgesic tests were lower than those with the extract. These results suggest that R. siamensis extract produces anti-nociceptive actions similar to those of a peripherally acting analgesic drug aspirin, and that pseudoginsenoside-RP1 may partly contribute, but is not the main contributor, to the antinociceptive action of the extract.
对暹罗茜树（Randia siamensis CRAIB，简称R. siamensis）提取物及其成分假人参皂苷-RP1进行了扭体试验、热板试验和Randall-Selitto试验，以检测其镇痛活性。在小鼠扭体试验中，口服暹罗茜树提取物可剂量依赖性地减少0.6%乙酸诱导的扭体和伸展次数。此外，在大鼠的Randall-Selitto试验中，该提取物提高了角叉菜胶致炎爪而非未致炎爪的痛觉阈值。它对小鼠热板试验中的痛觉反应没有影响。暹罗茜树提取物对小鼠戊巴比妥诱导的睡眠或自发运动活动没有影响，表明它没有镇静作用。假人参皂苷-RP1产生了与暹罗茜树提取物相似的效果，但在镇痛试验中的有效剂量低于提取物。这些结果表明，暹罗茜树提取物产生的抗伤害感受作用类似于外周作用的镇痛药阿司匹林，并且假人参皂苷-RP1可能部分但并非主要地促成了该提取物的抗伤害感受作用。
