McCrea A E, Stehouwer D J, Van Hartesveldt C
Department of Psychology, University of Florida, Gainesville 32611.
Brain Res Dev Brain Res. 1994 Oct 14;82(1-2):136-42. doi: 10.1016/0165-3806(94)90156-2.
The effects of several doses of L-DOPA (25, 50, 75 and 100 mg/kg) on air-stepping were studied in rats on the day of birth and on 5, 10, 15 and 20 days of age. Occurrence of air-stepping increased and latency to air-stepping generally decreased with dose except at 10 days of age; duration of air-stepping increased with increasing dose of L-DOPA at every age. The occurrence of a variety of air-stepping gaits was age-dependent. On the day of birth, air-stepping consisted primarily of episodes of forelimb alternation; on days 5-20, diagonal progression was the predominant gait, but beginning at day 10, episodes of air-swimming, air-galloping and other locomotor patterns were interspersed. Not only could the durations of most of these gaits be increased with increasing dose of L-DOPA, but at some ages, increasing the dose of L-DOPA led to gait changes.
在出生当天以及出生后5、10、15和20日龄的大鼠中，研究了几种剂量的左旋多巴（25、50、75和100毫克/千克）对空中踏步的影响。除了10日龄外，空中踏步的发生率随剂量增加而增加，空中踏步的潜伏期通常随剂量降低；在每个年龄阶段，空中踏步的持续时间随左旋多巴剂量的增加而增加。各种空中踏步步态的出现与年龄有关。出生当天，空中踏步主要由前肢交替的发作组成；在5 - 20日龄时，对角前进是主要步态，但从10日龄开始，穿插出现空中游泳、空中飞奔和其他运动模式的发作。不仅这些步态中的大多数持续时间会随着左旋多巴剂量的增加而延长，而且在某些年龄，增加左旋多巴剂量会导致步态改变。
