Romanowicz L, Bańkowski E, Jaworski S, Chyczewski L
Department of Biochemistry, Academy of Medicine, Białystok, Poland.
Folia Histochem Cytobiol. 1994;32(3):199-204.
It was found that the umbilical cord arteries (UCAs) contained several types of glycosaminoglycans (GAGs), including hyaluronic acid and sulphated glycosaminoglycans. EPH-gestosis is accompanied by significant changes in the composition of extracellular matrix of the UCAs. Significant increase in collagen content was found. Total amount of GAGs did not change much but the quantitative ratio between various GAGs distinctly altered. A decrease in hyaluronic acid content and an increase in the amount of sulphated GAGs as well as a diminution of GAGs/collagen ratio were observed. These observations were confirmed by histochemical methods. The significance of these phenomena for collagen fibrillogenesis in the arterial wall is discussed.
研究发现，脐动脉（UCA）含有几种类型的糖胺聚糖（GAG），包括透明质酸和硫酸化糖胺聚糖。子痫前期伴有脐动脉细胞外基质成分的显著变化。发现胶原蛋白含量显著增加。GAG的总量变化不大，但各种GAG之间的定量比例明显改变。观察到透明质酸含量降低、硫酸化GAG含量增加以及GAG/胶原蛋白比例减小。这些观察结果通过组织化学方法得到证实。讨论了这些现象对动脉壁胶原纤维形成的意义。
