Bańkowski E, Romanowicz L, Jaworski S
Department of Biochemistry, Institute of Obstetrics and Gynecology, Academy of Medicine, Białystok, Poland.
J Perinat Med. 1993;21(6):491-8. doi: 10.1515/jpme.1993.21.6.491.
We decided to investigate the EPH-gestosis--connected alterations in collagen of the umbilical cord arteries. The samples of arterial walls were submitted to histological and biochemical studies. It was found that umbilical cord arteries taken from newborns of mothers with EPH-gestosis contain more than twice the amount of collagen in comparison to corresponding arteries of newborns from normal pregnancies. An increase of collagen content in these vessels in accompanied by a slight decrease of its solubility. Types I, III, IV, V and VI collagens were found both in normal umbilical cord arteries and in those of newborns delivered by mothers with EPH-gestosis but their proportional relationships were different. EPH-gestosis is accompanied by an increase of a proportional amount of type III-collagen and a decrease of type I collagen in umbilical cord arteries. It seems that these changes in the umbilical cord arteries may be responsible for the decrease of blood flow in fetus of woman with EPH-gestosis.
我们决定研究与EPH-妊娠中毒症相关的脐动脉胶原变化。对动脉壁样本进行了组织学和生化研究。结果发现，与正常妊娠新生儿的相应动脉相比，取自患有EPH-妊娠中毒症母亲的新生儿的脐动脉中胶原含量多出两倍以上。这些血管中胶原含量的增加伴随着其溶解度的轻微降低。在正常脐动脉和患有EPH-妊娠中毒症母亲所生新生儿的脐动脉中均发现了I、III、IV、V和VI型胶原，但它们的比例关系不同。EPH-妊娠中毒症伴随着脐动脉中III型胶原比例的增加和I型胶原的减少。看来，脐动脉的这些变化可能是导致患有EPH-妊娠中毒症妇女胎儿血流减少的原因。
