Johnston B L, Schlech W F, Marrie T J
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
J Hosp Infect. 1994 Oct;28(2):103-12. doi: 10.1016/0195-6701(94)90137-6.
Five of 34 (15%) patients who received prosthetic cardiac valves between May and August 1982 at the Victoria General Hospital in Halifax, Nova Scotia, developed Candida parapsilosis prosthetic valve endocarditis. The clustering of these cases pointed to a common source outbreak. In a retrospective cohort study, no significant differences were found between infected and uninfected patients in terms of pre-, intra-, and postoperative risk factors. Environmental investigations suggested intraoperative contamination through the cardiac bypass equipment as the source of infection but a causal relationship could not be established. The outcome for the cases was uniformly fatal, emphasizing the need for prevention of such serious nosocomial infections.
1982年5月至8月间，在新斯科舍省哈利法克斯市维多利亚总医院接受人工心脏瓣膜植入手术的34名患者中有5名（15%）发生了近平滑念珠菌人工瓣膜心内膜炎。这些病例的聚集表明存在共同来源的暴发。在一项回顾性队列研究中，未发现感染患者与未感染患者在术前、术中和术后危险因素方面存在显著差异。环境调查表明，通过心脏搭桥设备的术中污染是感染源，但无法确定因果关系。这些病例的结局均为死亡，这凸显了预防此类严重医院感染的必要性。
