一组医学管理的近平滑念珠菌复合性人工瓣膜心内膜炎病例。
A case series of medically managed Candida parapsilosis complex prosthetic valve endocarditis.
机构信息
Department of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan road II, Guangzhou, Guangdong, China.
Department of Ultrasound, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
出版信息
Ann Clin Microbiol Antimicrob. 2021 Jan 5;20(1):1. doi: 10.1186/s12941-020-00409-4.
BACKGROUND
In recent years, Candida parapsilosis is recognized as a species complex and is composed of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. Candida parapsilosis complex prosthetic valve endocarditis (PVE) is rare and the survival rate is still low despite of optimal therapeutic strategies. In our report, it is novel to report cases as Candida parapsilosis complex PVE at species and identify Candida parapsilosis using MALDI-TOF MS. Case presentation A series of 4 cases of Candida parapsilosis complex PVE from our institution was reported. Three were infected by Candida parapsilosis sensu stricto and one was infected by Candida metapsilosis. The condition of two cases got better and the other died.
CONCLUSIONS
More attention should be paid to Candida parapsilosis complex PVE and early diagnosis and prompt antibiotic therapy may play a role in the treatment for Candida parapsilosis complex PVE. It is recommended to identify Candida parapsilosis complex at species level and MALDI-TOF MS as an easy, fast and efficient identification method is worth promoting in clinical microbiology.
背景
近年来，近平滑念珠菌被认为是一个种复合体，由近平滑念珠菌、中间型念珠菌和假热带念珠菌组成。尽管采用了最佳治疗策略，念珠菌复合假体瓣膜心内膜炎（PVE）仍然罕见，存活率仍然较低。在我们的报告中，使用 MALDI-TOF MS 对近平滑念珠菌复合 PVE 进行种水平鉴定是新颖的。
病例介绍
报告了来自我们机构的一系列 4 例近平滑念珠菌复合 PVE 病例。其中 3 例感染了近平滑念珠菌，1 例感染了假热带念珠菌。2 例病情好转，1 例死亡。
结论
应更加重视近平滑念珠菌复合 PVE，早期诊断和及时的抗生素治疗可能对近平滑念珠菌复合 PVE 的治疗有作用。建议在种水平上鉴定近平滑念珠菌复合种，MALDI-TOF MS 作为一种简便、快速、有效的鉴定方法，值得在临床微生物学中推广。
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