Ilieva P, Khalkova Zh, Zaĭkov Kh, Kapurdov V, Ivanova-Chemishanska L
Probl Khig. 1994;19:105-11.
The gonadotropic effect of the Bulgarian preparation artichoke, developed on the basis of Cynara scolymus is studied. The preparation is used under the form of 50% aque emulsion, stabilized by emulgent Twin-80, in doses 35.70 and 150 mg/kg-1, 5 times weekly for 75 days. The evaluation is made on sexually mature white male rats Wistar, distributed into groups of 10. The results are compared with a control group. A complex of functional, quantitative morphological, classic histological tests are used, in compliance with the Bulgarian State Standards 15378-81. An electron microscopic study is performed. The 75-day introduction of artichoke [Cynara scolymus] in doses 35.70 and 150 mg/kg-1 leads to no significant changes in the structure of the semen of white rats, established on cellular and subcellular level. The single deviations in the function of the spermatozoid and the morphology of the spermatogenic epithelium give no grounds for conclusion concerning an injury or stimulating effect of the preparation in the conditions of the experiment.
对以朝鲜蓟（Cynara scolymus）为基础研制的保加利亚制剂朝鲜蓟的促性腺作用进行了研究。该制剂以50%水乳液的形式使用，由乳化剂吐温-80稳定，剂量为35、70和150毫克/千克，每周5次，共75天。对性成熟的雄性Wistar大白鼠进行评估，每组10只。将结果与对照组进行比较。按照保加利亚国家标准15378 - 81，采用了一系列功能、定量形态学、经典组织学测试方法。进行了电子显微镜研究。以35、70和150毫克/千克的剂量连续75天给大白鼠注射朝鲜蓟制剂，在细胞和亚细胞水平上，大白鼠精液结构未出现显著变化。精子功能和生精上皮形态的个别偏差，不足以得出该制剂在实验条件下具有损伤或刺激作用的结论。
