Mikhaĭlova A, Antov G, Khristova V, Georgieva R, Zaprianov Z
Probl Khig. 1994;19:81-8.
A representative group of 122 workers from shop "Predilen" with 7 to 15 years length of service in specialty is taken. The professional groups are formed on the basis of measured average-shift concentrations of carbon bisulphide in the air of the working place, which vary from 4 to 50 mg.m-3. In order to establish deviations in some of the basic links of the biochemical mechanism of the toxic compounds effect the following indices are traced: copper metabolism [copper concentration and activity of ceruloplasmin in the serum]; lipidic metabolism [content of cholesterol, cholesterol of high and low density, triglycerides, beta-lipoproteins and nonesterified lipidic acids in the serum]; intercellular substance of the connective tissue [glycoproteins, glycosaminoglycans and hexauronic acids in serum and urine]; immune status [immunoglobulins A, G and M in serum]; peripheral blood [leucocytes, DKK, morphology and lipid content in granulocytes]. Decrease of the lipids in granulocytes is registered, as well as reduction of the ceruloplasmin activity, increase of immunoglobulin M and glycosaminoglycans in urine. The already established deviations follow the "dose-effect" and "dose-response" dependence.
选取了“Predilen”车间的122名有7至15年专业工龄的工人作为代表组。专业组是根据工作场所空气中二硫化碳的实测平均轮班浓度形成的，浓度范围为4至50毫克/立方米。为了确定有毒化合物作用的生化机制某些基本环节的偏差，追踪了以下指标：铜代谢[血清中铜的浓度和铜蓝蛋白的活性]；脂质代谢[血清中胆固醇、高密度和低密度胆固醇、甘油三酯、β脂蛋白和非酯化脂肪酸的含量]；结缔组织的细胞间质[血清和尿液中的糖蛋白、糖胺聚糖和己糖醛酸]；免疫状态[血清中的免疫球蛋白A、G和M]；外周血[白细胞、DKK、粒细胞的形态和脂质含量]。记录到粒细胞中脂质减少，以及铜蓝蛋白活性降低、尿液中免疫球蛋白M和糖胺聚糖增加。已确定的偏差遵循“剂量-效应”和“剂量-反应”依赖性。
