Biondi M, Peronti M, Pacitti F, Pancheri P, Pacifici R, Altieri I, Paris L, Zuccaro P
III Clinica Psichiatrica, University of Rome, La Sapienza, Italy.
Psychother Psychosom. 1994;62(3-4):176-84. doi: 10.1159/000288920.
The impact of stress and its neuroendocrine correlates on immune function are well established and individual variations could be attributed to modulation by personality characteristics. To assess the influence of everyday life stress and personality on neuroendocrine and immune function, we administered, to 18 healthy adults, the Minnesota Multiphasic Personality Inventory (MMPI) to assess their personality, the State-Trait Anxiety Inventory to measure anxiety, the Reaction Scheme Test to assess their coping reaction style, the Life Events Survey to assess the impact of stressful life events, and the Subjective Stress Questionnaire to assess perceived stress. The endocrine evaluation comprised prolactin, cortisol, and growth hormone plasma levels, while the immunological evaluation assessed T4, T8, and T11 lymphocyte percentages, as well as natural killer cell count and activity. All evaluations were made at baseline and after 8 months. We found a reduction of the T11 lymphocyte percentage to be accompanied by a reduction in the scores of the MMPI scale of Subtle Defensiveness and by an increase in the scores of the Social Introversion Scale. A positive correlation was found between prolactin and T4 lymphocyte percentage. These preliminary data show that some personality and endocrine measures correlate with immune function.
压力及其神经内分泌关联对免疫功能的影响已得到充分证实，个体差异可能归因于人格特征的调节作用。为评估日常生活压力和人格对神经内分泌及免疫功能的影响，我们对18名健康成年人进行了明尼苏达多相人格调查表（MMPI）以评估其人格，用状态-特质焦虑量表测量焦虑程度，通过反应模式测试评估其应对反应方式，采用生活事件调查评估应激性生活事件的影响，并使用主观压力问卷评估感知到的压力。内分泌评估包括催乳素、皮质醇和生长激素的血浆水平，而免疫学评估则测定T4、T8和T11淋巴细胞百分比，以及自然杀伤细胞计数和活性。所有评估均在基线时和8个月后进行。我们发现T11淋巴细胞百分比降低伴随着MMPI量表中细微防御性得分的降低以及社交内向性量表得分的升高。催乳素与T4淋巴细胞百分比之间存在正相关。这些初步数据表明，一些人格和内分泌指标与免疫功能相关。
