van Gool W A, Kuiper M A, Walstra G J, Wolters E C, Bolhuis P A
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands.
Ann Neurol. 1995 Feb;37(2):277-9. doi: 10.1002/ana.410370221.
Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease.
