Clerici M, Shearer G M
Cattedra di Immunologia, Universitá degli Studi, Milano, Italy.
Immunol Today. 1994 Dec;15(12):575-81. doi: 10.1016/0167-5699(94)90220-8.
In their earlier, much quoted, viewpoint article, Mario Clerici and Gene Shearer examined the role of T helper 1 (Th1)- and Th2-type responses in immune dysregulation associated with human immunodeficiency virus (HIV) infection. In this article, they consider the complications of a Th1-Th2 model raised by the nomenclature, discuss the issue of cytokine production by non-T cells, and compare data obtained from T-cell clones with heterogeneous populations of leukocytes from patients. They define Th-cell responses and cytokine profiles as 'type 1' and 'type 2', and reemphasize the importance of strong cellular immune responses, along with the cytokines that augment and maintain such responses, in protective immunity against HIV infection and AIDS progression. Finally, they present a model of activation-induced, cytokine-modulated, programmed cell death as a major factor in the pathogenesis of HIV infection and AIDS.
在他们早期那篇被大量引用的观点文章中，马里奥·克莱里西和吉恩·希勒探讨了辅助性T细胞1（Th1）型和Th2型反应在与人类免疫缺陷病毒（HIV）感染相关的免疫失调中的作用。在本文中，他们考量了命名法引发的Th1-Th2模型的复杂性，讨论了非T细胞产生细胞因子的问题，并比较了从T细胞克隆获得的数据与来自患者的异质性白细胞群体的数据。他们将Th细胞反应和细胞因子谱定义为“1型”和“2型”，并再次强调了强大的细胞免疫反应以及增强和维持这种反应的细胞因子在针对HIV感染和艾滋病进展的保护性免疫中的重要性。最后，他们提出了一种激活诱导、细胞因子调节的程序性细胞死亡模型，认为这是HIV感染和艾滋病发病机制中的一个主要因素。
