Bertram B, Haase G, Remky A, Reim M
Augenklinik, RWTH Aachen.
Ophthalmologe. 1994 Dec;91(6):768-71.
Elevated levels of anticardiolipin antibodies (ACA) have recently been found to be associated with occlusive diseases such as myocardial or cerebral infarction or venous thrombosis. In a prospective study anticardiolipin antibodies (both IgG and IgM) were measured by ELISA in 140 patients with acute vascular occlusions of the eye. Patients with clinical evidence for lupus erythematodes, HIV infection or elevated concentrations of antinuclear antibodies (IIFT with HEp-2 as antigen, LD Diagnostika, Heiden, FRG) were excluded. Elevated concentrations of IgG-ACA and IgM-ACA were found in 9% of the cases, with no correlation with the type of ocular vascular occlusion (retinal artery occlusion, retinal vein occlusion, anterior ischemic optic neuropathy). These results indicate that the anticardiolipin syndrome with elevated concentration of anticardiolipin antibodies may also have a causal role in some patients with occlusive eye diseases, whereas in most patients the concentrations were within normal ranges.
最近发现，抗心磷脂抗体（ACA）水平升高与诸如心肌梗死、脑梗死或静脉血栓形成等闭塞性疾病有关。在一项前瞻性研究中，采用酶联免疫吸附测定法（ELISA）检测了140例急性眼部血管闭塞患者的抗心磷脂抗体（IgG和IgM）。排除有红斑狼疮、HIV感染临床证据或抗核抗体浓度升高（以HEp-2作为抗原的间接免疫荧光法，LD Diagnostika公司，德国海德）的患者。9%的病例中发现IgG-ACA和IgM-ACA浓度升高，与眼部血管闭塞类型（视网膜动脉阻塞、视网膜静脉阻塞、前部缺血性视神经病变）无关。这些结果表明，抗心磷脂抗体浓度升高的抗心磷脂综合征在一些眼部闭塞性疾病患者中可能也起因果作用，而在大多数患者中，其浓度在正常范围内。
