Atchaneeyasakul La-Ongsri, Trinavarat Adisak, Bumrungsuk Parapun, Wongsawad Warapat
Department of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Jpn J Ophthalmol. 2005 May-Jun;49(3):211-5. doi: 10.1007/s10384-005-0190-3.
To assess the role of serum anticardiolipin IgG antibody and fasting plasma homocysteine levels as risk factors for retinal vascular occlusive disease in Thai patients.
This is a retrospective, case-control study. Forty-one consecutive patients with recent onset of retinal vascular occlusive diseases were enrolled. In conjunction with a routine laboratory work up, serum anticardiolipin IgG antibody and plasma homocysteine were evaluated. Ninety volunteers without a history of retinal vascular occlusive disease were chosen as controls.
In general, mean levels of anticardiolipin IgG antibody and homocysteine did not differ between the patients and controls. However, when the groups without a history of underlying systemic diseases were compared, there were statistically significant differences in the anticardiolipin IgG antibody level between patients and controls (mean 12.24 +/- 8.66 and 7.70 +/- 6.69 GPL units/ml, respectively) with a P value of 0.024.
No association was found between plasma homocysteine level and retinal vascular occlusion in our patient population. A high level of anticardiolipin IgG antibody is shown to be a risk factor only in patients without a history of underlying systemic diseases. The effect of anticardiolipin IgG antibody on the development of retinal vascular occlusive disease appears to be limited and may not be a major cause.
评估血清抗心磷脂IgG抗体和空腹血浆同型半胱氨酸水平作为泰国患者视网膜血管阻塞性疾病危险因素的作用。
这是一项回顾性病例对照研究。纳入41例近期发生视网膜血管阻塞性疾病的连续患者。在进行常规实验室检查的同时，评估血清抗心磷脂IgG抗体和血浆同型半胱氨酸。选择90名无视网膜血管阻塞疾病病史的志愿者作为对照。
总体而言，患者和对照组的抗心磷脂IgG抗体和同型半胱氨酸平均水平无差异。然而，在比较无潜在系统性疾病病史的组时，患者和对照组之间的抗心磷脂IgG抗体水平存在统计学显著差异（分别为平均12.24±8.66和7.70±6.69 GPL单位/毫升），P值为0.024。
在我们的患者群体中，未发现血浆同型半胱氨酸水平与视网膜血管阻塞之间存在关联。高水平的抗心磷脂IgG抗体仅在无潜在系统性疾病病史的患者中被证明是一个危险因素。抗心磷脂IgG抗体对视网膜血管阻塞性疾病发展的影响似乎有限，可能不是主要原因。
