Glacet-Bernard A, Bayani N, Chretien P, Cochard C, Lelong F, Coscas G
University Eye Clinic of Créteil, France.
Arch Ophthalmol. 1994 Jun;112(6):790-5. doi: 10.1001/archopht.1994.01090180088041.
To assess the prevalence of antiphospholipid antibodies in patients with occlusive retinal vascular disorders.
Seventy-five consecutive patients (44 with central retinal vein occlusions, 24 with branch venous occlusions, five with vasculitis plus branch venous occlusion, and two with arterial occlusions) were screened for antiphospholipid antibodies and compared with a control group composed of outpatients with similar systemic vascular disorders.
The antibody assay for one patient was positive for lupus anticoagulant and the antibody assay for three other patients was positive for anticardiolipin antibodies. These four patients had central or branch retinal vein occlusion and presented with several vascular risk factors. Comparison of the retinal vascular occlusion and the control groups showed no difference in the levels of anticardiolipin antibodies or lupus anticoagulant.
Antiphospholipid antibodies did not seem to be a feature of retinal vein occlusion, but in rare cases (5%) they may contribute to the occlusive phenomenon. A systematic screening does not seem to be justified, but it may be valuable to test for antiphospholipid antibodies in patients without conventional risk factors and in patients with clotting screen abnormalities, particularly if associated with lupus-like syndrome or other elements of the primary antiphospholipid syndrome.
评估抗磷脂抗体在视网膜血管阻塞性疾病患者中的患病率。
连续纳入75例患者（44例视网膜中央静脉阻塞、24例视网膜分支静脉阻塞、5例血管炎合并视网膜分支静脉阻塞和2例视网膜动脉阻塞），检测其抗磷脂抗体，并与由患有相似全身血管疾病的门诊患者组成的对照组进行比较。
1例患者狼疮抗凝物抗体检测呈阳性，另外3例患者抗心磷脂抗体检测呈阳性。这4例患者均患有视网膜中央或分支静脉阻塞，并伴有多种血管危险因素。视网膜血管阻塞组与对照组比较，抗心磷脂抗体或狼疮抗凝物水平无差异。
抗磷脂抗体似乎并非视网膜静脉阻塞的特征，但在罕见情况下（5%）可能与阻塞现象有关。系统性筛查似乎并无必要，但对于无传统危险因素的患者以及凝血筛查异常的患者，尤其是伴有狼疮样综合征或原发性抗磷脂综合征其他表现的患者，检测抗磷脂抗体可能有价值。
