Cytoskeletal reorganization underlying growth cone motility.

Recent studies have implicated cytoskeletal dynamics as an important component in directing neuronal outgrowth. By using modern imaging techniques to observe the kinetics of individual cytoskeletal elements in living cells, these results have converged upon a common theme: functional coupling between the intracellular cytoskeleton and extracellular substrates, and regulation thereof, appears to be crucial in controlling neuronal migration.