酵母（酿酒酵母）减数分裂过程中紫外线照射后DNA降解及重组减少
DNA Degradation and reduced recombination following UV irradiation during meiosis in yeast (Saccharomyces cerevisiae).
作者信息
Salts Y, Simchen G, Piñon R
出版信息
Mol Gen Genet. 1976 Jul 5;146(1):55-9. doi: 10.1007/BF00267983.
PMID:785210
Abstract
Irradiation of meiotic yeast cells with moderate doses of ultraviolet irradiation (1,600 erg/mm2) leads to the arrest of premeiotic DNA synthesis, massive (5-40%) DNA degradation, and a 40-50% loss of cell viability. In contrast, such doses of UV irradiation had a minor effect on viability (15-20% loss) of logarithmically growing cells, and no comparable DNA degradation was observed in irradiated synchronized vegetative cells. Meiotic recombination is also affected by UV irradiation. When administered at a stage comparable to meiotic prophase, low doses of irradiation result in a reduction in recombination frequency without significantly affecting cell viability.
摘要
用中等剂量的紫外线（1600尔格/平方毫米）照射减数分裂的酵母细胞会导致减数分裂前DNA合成停滞、大量（5%-40%）DNA降解以及细胞活力丧失40%-50%。相比之下，这种剂量的紫外线照射对对数生长期细胞的活力影响较小（活力丧失15%-20%），并且在照射同步化的营养细胞中未观察到类似的DNA降解。减数分裂重组也受紫外线照射的影响。当在与减数分裂前期相当的阶段进行照射时，低剂量照射会导致重组频率降低，而不会显著影响细胞活力。
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