Muramatsu Y, Takaesu Y
Department of Hygiene and Community Dentistry, Tokyo Dental College, Japan.
Bull Tokyo Dent Coll. 1994 Aug;35(3):139-51.
The purpose of this study was to investigate oral health status in relation to subgingival microflora and sex hormone concentrations in saliva during pregnancy. Oral health examinations were performed on 39 subjects: of 19 pregnant women (mean age 28.5), and 8 women in the fifth post-partum month (mean age 27.1), and 12 non-pregnant women (mean age 22.9). Periodontal conditions of bleeding on probing, redness, swelling, and probing depth were examined. Subgingival microbial compositions were examined with several selective media. Concentrations of estradiol and progesterone in saliva were determined during pregnancy and the first post-partum month. From the third to the fifth month of pregnancy, the number of gingival sites where probing caused bleeding increased concomitantly with increasing percentages of Prevotella intermedia. The number of gingival sites with redness and swelling increased in the fourth and seventh months of pregnancy and decreased in the last month of pregnancy to the level of the second month. The gingival inflammatory signs, however, tended to increase in the first post-partum month. The probing depth of gingiva gradually increased during pregnancy and the first post-partum month. Percentage of P. intermedia increased in the fourth month of pregnancy with increasing of hormones in saliva. The concentrations of hormones in saliva attained peaks in the ninth month of pregnancy. Thereafter, proportion of P. intermedia decreased. As a further step, these pregnant women were divided into three groups on the bases of percentages and detectable rates of P. intermedia. Gingival inflammation was more extensive in the high group subjects in which more than 15% P. intermedia in total CFU was detected; its severity also tended to increase.
本研究旨在调查孕期口腔健康状况与龈下微生物群及唾液中性激素浓度之间的关系。对39名受试者进行了口腔健康检查：19名孕妇（平均年龄28.5岁）、8名产后第五个月的女性（平均年龄27.1岁）和12名非孕妇（平均年龄22.9岁）。检查了探诊出血、发红、肿胀和探诊深度等牙周状况。用几种选择性培养基检查龈下微生物组成。在孕期和产后第一个月测定唾液中雌二醇和孕酮的浓度。从妊娠第三个月到第五个月，探诊引起出血的牙龈部位数量随着中间普氏菌百分比的增加而增加。发红和肿胀的牙龈部位数量在妊娠第四个月和第七个月增加，在妊娠最后一个月降至第二个月的水平。然而，牙龈炎症体征在产后第一个月往往会增加。牙龈探诊深度在孕期和产后第一个月逐渐增加。随着唾液中激素水平的升高，中间普氏菌的百分比在妊娠第四个月增加。唾液中激素浓度在妊娠第九个月达到峰值。此后，中间普氏菌的比例下降。进一步将这些孕妇根据中间普氏菌的百分比和可检测率分为三组。在总CFU中检测到超过15%中间普氏菌的高组受试者中，牙龈炎症更广泛；其严重程度也往往增加。
