Ferri R, Del Gracco S, Elia M, Musumeci S A, Scuderi C, Bergonzi P
Department of neurology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.
Neurophysiol Clin. 1994 Nov;24(5):357-66. doi: 10.1016/s0987-7053(05)80249-7.
Middle-latency somatosensory evoked potentials (MLSEPs) were recorded from 19 scalp electrodes in 19 patients with Down's syndrome (DS), in 13 age-matched normal controls and in 11 aged normal individuals. DS patients showed an increase in amplitude of P22, N30, P45, and N60. P100 latency was significantly shortened. After this potential, DS subjects showed the occurrence of a high voltage negative potential at around 100-110 msec followed by another high-voltage positive deflection; both these components showed a frontal-central distribution and were not observed in the two control groups. MLSEPs of DS subjects show peculiar alterations which could be supported by particular neurometabolic and/or neuropathologic changes.
在19名唐氏综合征（DS）患者、13名年龄匹配的正常对照者以及11名老年正常个体中，从19个头皮电极记录了中潜伏期体感诱发电位（MLSEP）。DS患者的P22、N30、P45和N60波幅增加。P100潜伏期显著缩短。在此电位之后，DS受试者在100 - 110毫秒左右出现一个高电压负电位，随后是另一个高电压正偏转；这两个成分均显示额中央分布，在两个对照组中未观察到。DS受试者的MLSEP显示出特殊改变，这可能由特定的神经代谢和/或神经病理变化所支持。
