Ferri R, Del Gracco S, Elia M, Musumeci S A, Spada R, Stefanini M C
Department of Neurology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina (EN), Italy.
Neurophysiol Clin. 1996;26(5):311-9. doi: 10.1016/S0987-7053(97)85098-8.
Middle-latency somatosensory evoked potentials (MLSEPs) were recorded in four groups of subjects: 13 normal young controls (mean age, 17.9 years). 11 normal elderly (mean age, 66.9 years), 11 patients with dementia of Alzheimer's type (DAT: mean age, 70.5), and four with vascular dementia (mean age, 79.3). MLSEPs in normal elderly showed an increase in the latency of P22, N30, P45, N60, and P100, and in the amplitude of N60. DAT patients also presented such changes; however, the increase in the amplitude of N60 was much more evident than that found in normal aging and was accompanied by a significant increase in amplitude of P45. Patients with vascular dementia tended to show longer latencies and larger amplitudes than the other groups. The increase in amplitude of P45 and N60 in MLSEPs seems to be characteristically associated with normal aging and the development of dementia. It is suggested that the mechanism of such functional changes might be correlated with the structural and neurochemical changes accompanying neuronal loss in these conditions.
在四组受试者中记录了中潜伏期体感诱发电位（MLSEP）：13名正常年轻对照者（平均年龄17.9岁）、11名正常老年人（平均年龄66.9岁）、11名阿尔茨海默病型痴呆（DAT）患者（平均年龄70.5岁）和4名血管性痴呆患者（平均年龄79.3岁）。正常老年人的MLSEP显示P22、N30、P45、N60和P100的潜伏期增加，以及N60的波幅增加。DAT患者也出现了此类变化；然而，N60波幅的增加比正常衰老中更为明显，并且伴随着P45波幅的显著增加。血管性痴呆患者的潜伏期往往比其他组更长，波幅更大。MLSEP中P45和N60波幅的增加似乎与正常衰老和痴呆的发展具有特征性关联。有人提出，这种功能变化的机制可能与这些情况下伴随神经元丢失的结构和神经化学变化相关。
